ObjectiveTo explore the clinical effect of mild hypothermia combined with dexmedetomidine in patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation, and provide reference for clinical treatment. Methods88 patients with spontaneous circulation recovery and continuous coma after cardiopulmonary resuscitation from August 2016 to December 2017 were selected as subjects. They were randomly divided into study group and control group, 40 cases each. The patients in the control group were treated with mild hypothermia for 72 hours on the basis of basic treatment. Patients in the study group were treated with dexmedetomidine intravenously for 5 days on the basis of treatment in the control group. The neuron-specific enolase levels were compared between the two groups immediately after admission, on the 5th day and the 10th day after admission. The recovery of consciousness, the recovery of reflexes, and the recovery time of muscle tone were compared between the two groups. ResultsImmediately after admission, there was no significant difference in neuron-specific enolase levels between the two groups (P＞0.05). On the 5th and 10th day of treatment, the neuron-specific enolase levels in the study group were significantly lower than those in the control group, and the difference was statistically significant (P＜0.01). The recovery of consciousness, recovery of reflex and recovery time of muscle tone in the study group were significantly shorter than those in the control group, and the difference was statistically significant (P＜0.01). ConclusionMild hypothermia combined with dexmedetomidine in patients with hypoxic ischemic encephalopathy after cardiopulmonary resuscitation can more effectively reduce serum neuron-specific enolase levels, shorten patient recovery, reflex recovery and muscle tension recovery time, promote the patient recovers and improves the prognosis of the patient.

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