ObjectiveTo investigate the clinical effect of coenzyme I in the treatment of children with viral myocarditis (VMC). Methods80 children with myocarditis admitted to our hospital from August 2015 to April 2017 were randomly divided into observation group and control group, with 40 cases in each group. The children in the control group were treated routinely, and the children in the observation group were given coenzyme I for injection on the basis of the treatment of the control group. The myocardial enzyme levels, cardiac function, and total effective rate of treatment were compared between the two groups. ResultsAfter 24 hours′ treatment, the levels of creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and mammary dehydrogenase (LDH) in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P＜0.05). The ejection fraction (EF), stroke volume (SV), and cardiac output (CO) levels of the observation group were significantly higher than those of the control group, and the difference was statistically significant (P＜0.05). After 7 days′ treatment, the total effective rate of treatment in the observation group (95.0%) was significantly higher than that in the control group (82.5%). The clinical efficacy was better than the control group, and the difference was statistically significant (P＜0.05). ConclusionCoenzyme I for injection is effective in the treatment of children with myocarditis, which is beneficial to improve myocardial enzyme level, enhance cardiac function and improve clinical treatment effect. It is worthy of clinical application.

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