ObjectiveTo investigate the application values of peritoneal dialysis combined with hemodialysis in treatment of patients with end-stage renal disease and inadequately peritoneal dialysis. MethodsA total of 46 cases of end-stage renal disease patients with inadequately peritoneal dialysis admitted to our hospital from April 2016 to September 2017 were selected as the research subjects and divided into control group and observation group by the random digital table method,with 23 cases in each group.The control group were increased the dose of peritoneal dialysis,while the observation group were combined with hemodialysis on the basis of the primary peritoneal dialysis dose.Compared with clinical efficacy,renal function index,inflammatory cytokine levels,immunological function status and adverse reactions between two groups. ResultsAfter 3 mouth treatment,total therapeutic efficiency of observation group （91.30%）was significantly higher than that in the control group （65.22%）,with statistical significance（P＜0.05）.The levels of BUN,Scr were significantly decreased in both groups,and those in the observation group were lower than control group,with statistical significance(P＜0.01).The levels of TNF-α,IL-6,IgG,IgA,IgM were significantly decreased in both groups,and those in the observation group were lower than control group,with statistical significance (P＜0.05).During the duration of therapy,the incidence of complications in observation group (4.35%) was significantly lower than control group, (36.09%),with statistical significance (P＜0.05). ConclusionThe peritoneal dialysis combined with hemodialysis could effectively improve the treatment effect of insufficient peritoneal dialysis patients, protect the residual renal function,mitigate inflammatory reaction and improve immune function,reduce the incidence of related complications.

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