ObjectiveTo observe the effect of diammonium glycyrrhizinate injection combined with large dose of gamma globulin in treatment of children with acute severe viral myocarditis. MethodsA total of 108 children with acute severe viral myocarditis were randomly divided into control group and study group,with 54 cases in each group.The control group were treated with large dose of gamma globulin,while the study group were treated with diammonium glycyrrhizinate injection combined with large dose of gamma globulin.The clinical efficacy of two groups were compared,the levels of serum interleukin-8 (IL-8),interleukin-17 (IL-17),tumor necrosis factor-alpha (TNF-α) and creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and creatine kinase (CK) were detected and compared before and after treatment between the two groups.The adverse reactions were observed and compared between two groups. ResultsAfter 14 days treatment,the total effective rate of study group (96.3%) was significantly higher than that of control group (81.5%),with statistical significance (P＜0.05).The serum levels of IL-8, IL-17,TNF-α and CK-MB, LDH,CK in two groups were significantly lower than those before treatment (P＜0.05),the above indexes in study group were significantly lower than those in the control group,with statistical significance (P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups in the course of treatment (P>0.05). ConclusionDiammonium glycyrrhizinate injection combined with large dose of gamma globulin is effective in the treatment of acute severe viral myocarditis in children,it can significantly relieve the inflammation of myocardial cells,correct immune dysfunction and promote the recovery of children.

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