ObjectiveTo investigate the effects of high blood flow and high dialysate flow dialysis on microinflammation and nutritional status in maintenance hemodialysis patients. Methods80 patients who underwent maintenance hemodialysis in our hospital′s blood purification center from June 2014 to December 2014 were enrolled in the study. They were randomly divided into two groups, 40 in each group. The control group were given routine blood flow and conventional dialysate flow dialysis treatment. The blood flow was set to 250-300 mL/min, and the dialysate flow was set to 500 mL/min. The observation group were given high blood flow and high dialysate flow dialysis treatment. The blood flow was set to 300-350 mL/min, and the dialysate flow was set to 800 mL/min. The microinflammation status and nutritional status of the two groups were compared. ResultsAfter 1 month and 6 months of treatment, the levels of TNF-α, IL-6 and hs-CRP in the two groups were significantly decreased. The levels of TNF-α, IL-6 and hs-CRP in the observation group were significantly lower than those in the control group. The difference was statistically significant (P＜0.05). The levels of serum albumin (ALB), total protein (TP) and hemoglobin (Hb) in the two groups were significantly increased. The ALB, TP and Hb levels in the observation group were significantly higher than those in the control group (P＜0.05). ConclusionHigh blood flow and high dialysate flow dialysis treatment can effectively improve the microinflammatory state and nutritional status of maintenance hemodialysis patients, and improve the clinical treatment effect.

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