ObjectiveTo compare the clinical efficacy and safety of citrate caffeine and aminophylline in the treatment of primary apnea in premature infants. MethodsThe primary apnea premature infants admitted to our hospital from May 2016 to May 2017 were randomly divided into two groups, who were treated with citrate caffeine injection and aminophylline injection respectively. The number of apneas, invasive mechanical ventilation and non-invasive mechanical ventilation, and duration of oxygen inhalation were compared between the two groups. The incidence of tachycardia, decreased blood pressure, feeding intolerance, and hyperglycemia were compared between the two groups too. ResultsAfter 7 days of treatment, the average number of apneas, non-invasive mechanical ventilation duration, invasive mechanical ventilation duration, and oxygen inhalation duration in 72 h were significantly less in the caffeine group than in the aminophylline group, which was statistically significant (P＜0.05). The incidence of tachycardia in the caffeine group (19.2%) was significantly lower than that in the aminophylline group (30.3%), and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of blood pressure, feeding intolerance, and hyperglycemia between the two groups (P＞0.05). ConclusionThe efficacy and safety of caffeine in the treatment of apnea in preterm infants are higher than those in aminophylline.

无