ObjectiveTo investigate the clinical effects of cyclophosphamide shock combined with hormone therapy in patients with systemic lupus erythematosus. Methods66 patients with systemic lupus erythematosus who were treated in our hospital from March 2016 to May 2017 were selected. They were randomly divided into control group and observation group, with 33 cases in each group. The control group were treated with hormone therapy, the observation group were given cyclophosphamide shock therapy on the basis of the control group. Both groups were treated for 12 months. The immune function was compared between the two groups before and after treatment. The clinical efficacy and adverse reactions of the two groups were compared. ResultsAfter 1 week of treatment, the levels of C3, C4, IgM, IgG, and IgA in the two groups were significantly improved (P＜0.05). The improvement of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). At the end of the treatment period, the total effective rate of treatment in the observation group (93.94%) was significantly higher than that in the control group (75.76%), and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment (P＞0.05). ConclusionCyclophosphamide shock combined with hormone therapy treat systemic lupus erythematosus patients can significantly improve whose immune function, clinical treatment, and it′s safe and reliable.

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