ObjectiveTo investigate the clinical efficacy of Pibi Furen decoction combined with cinepazide maleate in the treatment of type 2 diabetic peripheral neuropathy and its effect on the level of oxidative stress. Methods96 patients with type 2 diabetic peripheral neuropathy were selected as the study subjects, and they were randomly divided into control group and observation group, 48 cases in each group. Both groups were given basic treatment for diabetes. The control group added to treat with cinepazide maleate, and the observation group were treated with Pibi Furen Decoction on the basis of the treatment of the control group. The clinical efficacy of the two groups of patients was compared. The levels of oxidative stress were compared between the two groups before and after treatment. The adverse reactions of the two groups were compared during the treatment. ResultsAfter 1 month′s treatment, the total effective rate of treatment in the observation group (93.8%) was significantly higher than that of the control group (75.0%), and the clinical efficacy was significantly better than the control group, the difference was statistically significant(P＜0.05). The MDA of the two groups were significantly decreased, and the SOD was significantly increased. The MDA of the observation group was significantly lower than that of the control group and the SOD was significantly higher than the control group (P＜0.05). There were no obvious adverse reactions in the two groups of patients during the treatment. ConclusionThe effect of Pibi Furen decoction combined with cinepazide maleate in the treatment of type 2 diabetic peripheral neuropathy is better than that of cinepazide maleate alone, which can effectively alleviate oxidative stress in patients.

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