ObjectiveTo investigate the clinical effect of doxofylline combined with dexamethasone in the treatment of coal-workers with pneumoconiosis complicated with pulmonary infection and its influences on lung function and blood routine test. Methods86 cases of coal-workers with pneumoconiosis complicated with pulmonary infection treated in our hospital from February 2016 to August 2017 were selected and randomly divided into observation group and control group, with 43 cases in each group. The two groups were given routine treatment. On this basis, the control group were treated with dexamethasone, the observation group were treated with doxofylline on the basis of of the therapeutic method of control group. The clinical curative effect, lung function, blood routine test and arterial blood gas analysis were compared between the two groups. ResultsAfter 1 month treatment, the total effective rate of the observation group was 95.35%, which was significantly higher than 76.74% of the control group (P＜0.05); the lung function of the two groups after the treatment were higher than those before the treatment. The observation group was higher than the control group (P＜0.05). The white blood cell and neutrophil counts of the two groups were significantly reduced. The white blood cell and neutrophil counts of the observation group were significantly lower than the control group (P＜0.05). The blood oxygen partial pressure (PO2) and pH in the two groups were higher than before the treatment (P＜0.05), the blood carbon dioxide partial pressure (PCO2) was lower than that before treatment (P＜0.05), and the PO2 and pH in the observation group were higher than those in the control group (P＜0.05), the PCO2 was lower than that in the control group (P＜0.05). ConclusionThe combination of doxofylline and dexamethasone in the treatment of coal-workers with pneumoconiosis complicated with pulmonary infection is clinically effective, which can effectively improve lung function and respiratory status, reduce lung inflammation.

无