ObjectiveTo investigate the correlation of serum B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), red cell distribution width (RDW) with the severity of chronic obstructive pulmonary disease (COPD). Methods139 cases with acute exacerbation COPD in our hospital from May 2016 to October 2017 and 70 healthy people during the same period were selected as study subjects. The patients with acute exacerbation COPD who had just been admitted to our hospital were set as the acute group, and the patients who had reached the stable COPD standard after treatment were set as stable group, and the healthy volunteers were set as the control group. The levels of serum BNP, hs-CRP and RWD in the three groups were compared. The levels of BNP, hs-CRP and RWD in the acute group with different GOLD grade were compared. Spearman correlation analysis of BNP, hs-CRP and RWD levels with GOLD grade were performed. ResultsThe levels of serum BNP, hs-CRP and RDW in the three groups were statistically difference (P＜0.05). The levels of serum BNP, hs-CRP and RDW in acute group were significantly higher than that of stable group and control group (P＜0.05). The levels of serum BNP, hs-CRP and RDW in stable group were significantly higher than that of control group (P＜0.05). The levels of serum BNP, hs-CRP and RDW in patients with acute exacerbation COPD were significantly increased with severity of COPD (P＜0.05). Spearman correlation analysis showed that levels of serum BNP, hs-CRP and RDW in acute group had positive correlation with GOLD grade (r=0.649, P=0.000; r=0.433, P=0.005; r=0.411, P=0.007). ConclusionThe levels of serum BNP, hs-CRP and RDW in patients with AECOPD had emerge rise trend with the severity of disease. Combined detection of serum BNP, hs-CRP and RDW levels has potential assessment value for the prognosis of early diagnosis and evaluation of severity of COPD.

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