ObjectiveTo explore the therapeutic effect of simple plasma exchange (PE) and PE combined with double plasma molecular adsorbent system (DPMAS) on patients with severe hepatitis. Methods60 patients with severe hepatitis treated in our hospital from January 2012 to December 2017 were selected and randomly divided into observation group and control group, with 30 cases in each group. The control group were treated with PE, the observation group were treated with PE combined with DPMAS. The serum total bilirubin (TBIL) level, serum direct bilirubin (DBIL) level, alanine aminotransferase (ALT) level, prothrombin time (PT), cholinesterase (CHE) level, albumin (ALB) level and globulin (GLO) level before and after treatment were compared between two groups. ResultsAfter treatment, the levels serum TBIL, DBIL and ALT were significantly decreased in the two groups. The levels of TBIL, DBIL and ALT in the observation group were significantly lower than those in the control group (P＜0.05). After treatment, the serum PT in the two groups were significantly decreased and the CHE level were significantly increased; the serum PT of the observation group was significantly lower than the control group, CHE level was significantly higher than the control group, the difference were statistically significant (P＜0.05). After treatment, the levels of serum ALB and GLO in the two groups were significantly higher than before treatment, the levels of serum ALB and GLO in the observation group were significantly higher than those in the control group (P＜0.05). ConclusionPE combined with DPMAS in the treatment of severe hepatitis patients can improve the liver damage, remove macromolecules such as small and medium molecular metabolic toxins and immune complexes, reduce the damage of blood forming components, and effectively reduce the risk occurrence of multiple organ failure.

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