ObjectiveTo compare the efficacy and safety of valproate and levetiracetam in the treatment of pediatric epilepsy. Methods72 cases of epileptic children treated in our hospital from October 2015 to October 2017 were selected and randomly divided into group A and group B, with 36 cases in each group. Group A were treated with valproate and group B were treated with levetiracetam. After 2 months of treatment, the clinical efficacy, improvement rate of epileptiform discharge, the levels of serum calcium and phosphorus, cognitive function and incidence of adverse reactions were compared between the two groups. ResultsAfter 2 months of treatment, the improvement rate of epileptiform discharge in group B (91.67%) was significantly higher than that in group A (72.22%), the levels of blood calcium and phosphorus were significantly lower than that of group A; the scores of language IQ, operational IQ and total IQ in group B were obviously superior to that of group A (P＜0.05). The total effective rate and adverse reactions rate were compared between the two groups, the differences were not statistically significant (P＞0.05). ConclusionThe valproate and levetiracetam in treatment of children with epilepsy both are remarkable and safety, but levetiracetam is more beneficial to EEG, the levels of blood calcium and phosphorus, and cognitive function for children with epilepsy.

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