ObjectiveTo explore the changes of serum liver and kidney function indicators in healthy pregnant women in Baoan District of Shenzhen City and establish a reference range of normal value. MethodsThe healthy pregnant women who were pregnant for 4 to 40 weeks from November 2017 to August 2018 in Shenzhen Baoan District Maternal and Child Healthcare Hospital and Community Rehabilitation Center were selected as subjects. Grouping by their age and pregnancy, the blood samples were collected and analyzed for liver and kidney function indicators. According to the test results, the normal reference range of serum liver and kidney function indicators of healthy pregnant women in Baoan District of Shenzhen City was established. ResultsThere were statistically significant differences in liver and kidney function indexes between healthy women of different ages. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bile acid (TBA), bicarbonate Salt (HCO3-), creatinine (Cr), uric acid (UA) levels in pregnant women of low-age group (19-32 years old) were lower than those in high age group (33-45 years old). Serum total protein (TP), albumin (ALB), total bilirubin (TBIL), urea (Ur) levels were higher than those in high age group, and the difference was statistically significant (P＜0.05). There were significant differences in liver and kidney function between healthy pregnant women with different pregnancy stages (P＜0.05). The levels of serum ALP and UA increased with gestational age. The levels of serum TP, ALB, TBIL, HCO3-, Cr decreased with gestational age. ConclusionThere are significant differences in serum liver and kidney function indicators between healthy women of different ages and different pregnancy stages. Establishing a reference interval for liver and kidney function indicators in pregnant women in different regions is of great significance for the diagnosis, prevention and treatment of gestational diseases.

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