ObjectiveTo investigate the clinical effect of Yiqi Jianpi Decoction assisted with metformin for patients with type 2 diabetes mellitus of spleen-qi deficiency. MethodsA total of 50 patients with type 2 diabetes mellitus of spleen-qi deficiency who were treated in our hospital from March 2017 to February 2018 were selected as subjects and randomly divided into the control group and the observation group, with 25 cases in each group. Two groups underwent basic treatments such as diet and exercise. On this basis, patients in control group were treated with metformin, and observation group were further treated with Yiqi Jianpi Decoction on the treatment of control group. The patients in two groups were treated for 3 months. Traditional Chinese medicine(TCM) syndrome score, glycated hemoglobin level, blood glucose level, and insulin level were compared between the two groups. ResultsAfter treatment for 3 months, the TCM syndrome score of two groups and the glycated hemoglobin level of the observation group were significantly decreased, the TCM syndrome score and glycated hemoglobin level of observation group were significantly lower than those in control group, and the difference was statistically significant (P＜0.05). The fasting blood glucose, 1-hour postprandial blood glucose and 2-hour postprandial blood glucose levels were significantly decreased in two groups and observation group were significantly lower than control group on these indicators, and the difference was statistically significant (P＜0.05). The fasting insulin level and insulin resistance index were significantly decreased in two groups and observation group were significantly lower than the control group on these indicators, the difference was statistically significant (P＜0.05). ConclusionYiqi Jianpi Decoction can effectively alleviate TCM syndrome, improve glucose metabolism and insulin resistance in patients with type 2 diabetes mellitus whose spleen-qi are deficient.

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