目的探究持续气道正压通气(CPAP)治疗非急性期脑梗死合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的临床疗效。方法选取2015年3月至2018年3月我院收治的非急性期脑梗死合并OSAHS患者80例作为研究对象,采用随机数字表法分成对照组(43例)和观察组(37例)。对照组患者给予脑梗死常规治疗,观察组患者在对照组治疗基础上给予CPAP治疗。两组患者均持续治疗6个月。比较两组患者治疗前后的D-二聚体水平、Epworth嗜睡量表(ESS)评分、Barthel指数量表(BI)评分、简易智力状态检查量表(MMSE)评分、汉密尔顿焦虑量表(HAMA)评分和汉密尔顿抑郁量表(HAMD)评分。结果治疗6个月后,观察组患者D-二聚体水平显著低于对照组(P<0.05)。观察组患者ESS评分、HAMA评分、HAMD评分显著低于对照组,BI及MMSE评分显著高于对照组,差异有统计学意义(P<0.05)。结论采用CPAP治疗非急性期脑梗死合并OSAHS患者,可显著改善其睡眠质量,提高其智力认知水平及日常生活能力,改善其负面情绪。
ObjectiveTo investigate the clinical efficacy of continuous positive airway pressure (CPAP) for patients with non-acute cerebral infarction complicated with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods80 patients with non-acute cerebral infarction complicated with OSAHS admitted to our hospital from March 2015 to March 2018 were selected and randomly divided into the control group (43 cases) and the observation group (37 cases). Patients in the control group received routine treatment for cerebral infarction, and patients in the observation group received CPAP treatment on the treatment of the control group. The patients in two groups of were continuously treated for 6 months. D-dimer levels, Epworth sleepiness scale (ESS) score, Barthel index scale (BI) score, Mini mental state examination scale (MMSE) score, Hamilton Anxiety Scale (HAMA) score, Hamilton depressive scale(HAMD) score before and after treatment were compared between the two groups. ResultsAfter 6 months of treatment, the D-dimer level ESS score, HAMA score and HAMD score of the observation group were significantly lower than those in the control group, and the BI and MMSE scores were significantly higher than the those in control group , the difference was statistically significant (P<0.05). ConclusionCPAP on patients with non-acute cerebral infarction complicated with OSAHS can significantly improve their sleep quality, improve their intellectual cognition and daily living ability, and improve their negative emotions.