ObjectiveTo investigate the correlation between polymorphisms of mitogen-activated protein kinases 1（MAPK1）gene rs6928, rs13515 and rs1063311 and MAPK1 mRNA expression and the degree of neurological deficits in patients with ischemic stroke(IS). MethodsGenotypes of MAPK1 gene rs6928, rs13515 and rs1063311 were detected using Massarray SNP genotyping technique, MAPK1 mRNA expression was assessed by qRT-PCR, and the degree of neurological deficits in patients with IS was evaluated using NIHSS score. ResultsAfter adjusting for gender and age, the polymorphisms of rs6928 was associated with NIHSS score in patients with IS in the additive model and recessive model(P＜0.05). The MAPK1 mRNA expression was not correlated to NIHSS score in IS patients (P＞0.05). ConclusionThe polymorphism of MAPK1 gene rs6928 may affect the degree of neurological deficits in patients with IS.

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