ObjectiveTo compare the clinical efficacy of anticoagulation and dual antiplatelet aggregation in the treatment of early progressive cerebral infarction. MethodsA total of 82 patients with early progressive cerebral infarction admitted to our hospital from April 2014 to April 2017 were randomly divided into anticoagulation group and antiplatelet group according to the order of admission. On the basis of conventional treatment, the anticoagulant group was given low molecular weight heparin calcium anticoagulant therapy and the antiplatelet group was given double antiplatelet aggregation therapy. The NIHSS score, the mRS score and Barthel score of 14 days after treatment of the two groups were compared. The total effective rate of treatment and incidence of hemorrhagic adverse complications of the two groups were compared. ResultsThere was significant difference in NIHSS scores between the two groups before treatment, 1 day, 7 days and 14 days after treatment (P＜0.05).The total effective rates of anticoagulation group in 7 days and 14 days after treatment were significantly higher than those of antiplatelet group, the difference was statistically significant (P＜0.05). The mRS score in the anticoagulation group was lower than that in the antiplatelet group, and Barthel score was higher than that in antiplatelet group, the difference was statistically significant (P＜0.05). During the treatment period, no hemorrhagic complications such as cerebral hemorrhage and gastrointestinal bleeding occurred in the two groups. ConclusionCompared with double antiplatelet aggregation therapy, anticoagulant therapy is more effective in patients with early progressive cerebral infarction, which can better improve neurological deficits, restore their living ability and improve prognosis.

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