ObjectiveTo explore the clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum Interleukin-8（IL-8）, procalcitonin（PCT）and tumor necrosis factor-α（TNF-α）levels. Methods96 patients with acute bacterial enteritis who were admitted to our hospital from April 2017 to July 2018 were selected as the research objects and randomly divided into observation group and control group, with 48 cases in each group. On the basis of conventional treatment, the observation group was treated with cefixime and control group was treated with cefaclor. Both groups were treated for 7 days. The clinical effects and diarrhea were compared between the two groups. The serum IL-8, PCT and TNF-α levels before and after treatment in the two groups were detected and compared. ResultsAfter 7 days of treatment, the total effective rate of observation group (97.92%) was significantly higher than that of the control group (72.92%), the diarrhea frequency was significantly less than that in the control group and the levels of serum IL-8, PCT and TNF-α were significantly lower than those in the control group, the difference was statistically significant (P＜0.05). ConclusionOn the basis of conventional treatment, cefixime is definite in clinical efficacy in treating patients with acute bacterial enteritis, which can effectively improve the symptoms of diarrhea and reduce the level of serum inflammatory factors.

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