ObjectiveTo analyze the clinical effect of serum cystatin C(Cys C) in early renal function injury patients caused by hypertension. Methods186 patients with essential hypertension were divided into hypertension gradeⅠgroup, hypertension grade Ⅱgroup, hypertension gradeⅢ group according to the degree of high blood pressure,62 cases in each group. The level of GFR and Cys C were detected, and the correlation analysis between GFR, Cys C and the degree of essential hypertension was carried out. ResultsThe value of GFR in hypertension gradeⅠgroup was higher than that in hypertension grade Ⅱgroup,and the hypertension gradeⅢ group was the least, the difference between the three groups was statistically significant(P＜0.05); the level of serum Cys-C had statistical significance in three groups (P＜0.05), and the level of serum Cys-C increase with the renal function impairmen; there was no significant difference in detecting rate of the serum creatinine, urea nitrogen, uric acid in three groups(P＞0.05) .The correlation analysis results show that the level of blood pressure was negatively correlated to GFR(r=-0.491) but positive correlated with serum Cys-C(r=0.835). ConclusionsThe detection of serum Cys C is simple, rapid and sensitive, it can be an index for diagnosis and predicting of renal dysfunction in patients with hypertension,which is worth to populate and apply.

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