ObjectiveTo explore the effect of comprehensive preventive intervention on HIV transmission between HIV single-positive families and on blood routine and CD4 cells in HIV/AIDS patients. MethodsA total of 205 pairs of HIV/AIDS patients and their HIV-negative spouses (i.e., HIV single-positive families) were selected from the outpatients of our hospital from September to December 2015. They were treated with comprehensive interventions including antiviral therapy. Intervention effects were assessed by routine testing of negative partner HIV antibodies, of positive patients CD4 cells and their peripheral blood cells. ResultsAfter comprehensive interventions, 205 pairs of HIV single-positive families were followed up for 24 months, no HIV antibody positive conversion was observed in all negative spouses in the families. There were statistically significant differences in WBC count in HIV single-positive family patients at different times (P＜0.05), and the WBC count increased with the raise of intervention time. There were statistically significant differences in CD4 cell count on patients at different times (P＜0.05) , and the CD4 cell count increased with the raise of intervention time. There were no statistically significant differences in TLC count, PLT count, RBC (male) count, RBC (female) count, HGB (male), and HGB (female) at different times (P＞0.05). There were correlations between CD4 cell count, WBC count and TLC count at each time point in HIV single-positive family patients (P＜0.05). There were weak correlations between CD4 cell count and PLT count at 12 months after intervention (P＜0.05) , and between CD4 cell count and HGB before intervention (P＜0.05). There was no correlation between CD4 cell count and RBC count at each time point (P＞0.05). ConclusionThe use of comprehensive measures including antiviral therapy to prevent couples in HIV single-positive families can effectively control the spread of HIV among spouses and improve levels of the WBC count and CD4 cell count in HIV/AIDS patients.

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