ObjectiveTo explore the application effect of sodium citrate local anticoagulation in continuous renal replacement therapy on critically ill patients. MethodsA total of 84 critically ill patients who underwent continuous renal replacement therapy in our hospital from November 2015 to February 2018 were selected and randomly divided into observation group and control group, with 42 cases in each group. The control group received unfractionated heparin for anticoagulation, and the observation group received 4% sodium citrate for local anticoagulation. The bleeding and coagulation condition, the changes of renal function and electrolytes as well as the occurrence of adverse reactions between the two groups were compared. ResultsThe bleeding rate of the observation group (2.38%) was significantly lower than that in the control group (19.05%), and the difference was statistically significant (P＜0.05). There was no statistically significant difference in the coagulation rate between the two groups (P＞0.05). After treatment for 24 hours, the levels of Ca+ and HCO3- in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P＜0.05). Six months after treatment, the levels of urea nitrogen (BUN) and serum creatinine (Scr) in both groups were significantly decreased (P＜0.05); however, there was no statistically significant difference in BUN and Scr levels between the two groups (P＞0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period (P＞0.05). ConclusionApplication sodium citrate local anticoagulation to continuous renal replacement therapy on critically ill patients can obtain effective anticoagulation, which shows little side effect on the renal function, and is beneficial to maintain electrolyte stability of the patients.

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