ObjectiveTo compare the clinical efficacy and treatment safety of oral with intramuscular injection of progesterone on threatened abortion caused by luteal phase defect. MethodsA total of 90 patients with threatened abortion caused by luteal phase defect admitted to our department of gynecology and obstetrics of our hospital from January 2017 to March 2018 were selected as the objects. They were randomly divided into observation group and control group, with 45 cases in each group. The observation group was treated with oral progesterone, whereas the control group was treated with intramuscular injection of progesterone, with two-week continuous treatment and one-month observation. ResultsThe success rate of tocolysis in the observation group was 93.33%, whereas 91.11% in the control group, with no statistically significant difference of comparison between the two groups (P＞0.05). There was no statistically significant difference of comparison in the relief time of lumbago, relief time of abdominal pain and hemostasis time between the two groups (P＞0.05). During treating period, the total incidence of adverse reactions was 6.7% in the observation group, while 20.0% in the control group. The difference of comparison between the two groups was statistically significant (P＜0.05). ConclusionThe effect of oral and intramuscular injection of progesterone in the treatment of threatened abortion has little difference on the success rate of tocolysis and on the effect of clinical symptom relief, while the incidence of adverse reactions in oral therapy is lower, which is worthy of clinical application.

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