ObjectiveTo observe the effect of early enteral nutrition on immune function and nutritional status in patients with acute pancreatitis complicated with multiple organ failure. MethodsA total of 98 patients with acute pancreatitis complicated with multiple organ failure admitted to our hospital from February 2017 to August 2018 were selected, and were divided into two groups according to random number table method, with 49 cases in each group. Both groups received conventional comprehensive treatment. On the basis of conventional comprehensive treatment, the control group received support of delayed enteral nutrition (DEN), and the observation group received early enteral nutrition (EEN) support. The changes of immune index, nutritional status index and clinical relevant indicators were compared between the two groups. ResultsAfter 2 weeks of treatment, the CD3+ cells, CD4+ cells, CD4+/CD8+cells, NK cells, B lymphocytes, IgA, IgG, and IgM levels were increased in the two groups, and the levels were significantly higher in the observation group than in the control group, with statistically significant difference ( P＜0.05). The levels of prealbumin (PA), transferrin (TRF) and albumin (Alb) were increased in the two groups, whereas the levels of the observation group were significantly higher than those of the control group. The difference was statistically significant (P＜0.05). The APACHE II score of the observation group was significantly lower than that of the control group, and the improvement time of SIRS and hospital stays were significantly shorter in the observation group than in the control group, with statistically significant difference (P＜0.05). ConclusionThe support of EEN on acute pancreatitis complicated with multiple organ failure can effectively enhance the immune function, improve nutritional status and clinical symptoms. It is beneficial to promote a speedy recovery of patients.

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