ObjectiveTo investigate the effect of fiber bronchoscopic alveolar lavage on blood gas analysis and serological indexes in patients with acute severe pneumonia and comorbid respiratory failure. MethodsA total of 60 patients with acute severe pneumonia and comorbid respiratory failure admitted to the department of emergency of our hospital from March 2016 to February 2018 were selected as the objects. All patients were numbered, and divided into control group and observation group according to single and double numbers, with 30 cases in each group. The control group was treated with conventional treatment, and the observation group was treated with conventional treatment plus fiber bronchoscopic alveolar lavage. The partial arterial oxygen pressure (PaO2), the partial pressure of carbon dioxide in arterial blood (PaCO2), oxygenation index (PaO2/FiO2), CD11B positive neutrophil ratio, high-mobility group box-1 (HMGB-1), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels were detected and compared between the two groups before treatment and on the third day of treatment. ResultsBefore treatment, there were no statistically significant differences in PaO2, PaCO2, PaO2/FiO2, CD11B positive neutrophil ratio, sTREM-1 level and HMGB-1 level between the two groups (P＞0.05). On the third day of treatment, PaO2 and PaO2/FiO2 were significantly higher in the observation group than in the control group, whereas PaCO2, CD11B positive neutrophil ratio, sTREM-1 and HMGB-1 levels were significantly lower than those of the control group, with statistically significant difference (P＜0.05). ConclusionPatients with acute severe pneumonia and comorbid respiratory failure treated with fiber bronchoscopic alveolar lavage can effectively improve blood gas analysis and serological indicators, and it is worthy of clinical promotion and application.

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