ObjectiveTo compare the CT angiography (CTA) of head and neck and the levels of C-reactive protein (CRP), homocysteine (Hcy), fibrinogen (FIB) and D-dimer (D-D) between patients with progressive cerebral infarction (PCI) and non-progressive cerebral infarction (NPCI). MethodsClinical data of 173 patients with anterior circulation acute cerebral infarction were analyzed retrospectively. Patients were divided into PCI group (56 cases) and NPCI group (117 cases) according to disease condition. The degree of head and neck vascular stenosis and plaque properties were compared between the two groups. The levels of serum CRP, Hcy, FIB and D-D at the time of admission, and on the 3rd day of admission were compared between the two groups. ResultsCompared to the NPCI group, patients in the PCI group obtained a higher incidence of artery stenosis (92.9% vs. 55.6%), and a larger proportion of moderate to severe artery stenosis in head and neck, with the statistically significant differences (P＜0.05). The proportion of unstable plaque, soft plaque, and mixed plaque in the PCI group was higher than those in the NPCI group, and the differences were statistically significant (P＜0.05). At the time of admission, there were no statistically significant differences in serum CRP, Hcy, FIB and D-D levels between the two groups (P＞0.05); while the serum CRP, Hcy, FIB and D-D levels of the PCI group 3 days after admission were higher than those of the NPCI group, with the statistically significant differences (P＜0.05). ConclusionPCI is closely related to the degree of head and neck artery stenosis and the plaque properties in patients. The serum CRP, Hcy, FIB, and D-D levels increase significantly in the early stage of PCI, for the CTA examination combined with the results of the abovementioned serum indicators can be used as an important basis for early screening of PCI patients.

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