ObjectiveTo investigate the effect of continuous blood purification on serum lactic acid (LA), procalcitonin (PCT), C-reactive protein (CRP) levels and prognosis in ICU patients with sepsis. MethodsA total of 70 patients with sepsis admitted to our hospital from February 2017 to January 2019 were selected as the research subjects and randomly divided into control group and observation group, with 35 cases in each group. Both groups received routine treatment for severe sepsis, based on which the control group was administered ulinastatin, whereas the observation group with ulinastatin + continuous blood purification treatment. Serum LA, PCT, CRP levels before and after treatment between the two groups were detected and compared. The ICU stays and twenty-eight-day mortality after therapy between the two groups were compared. ResultsBefore treatment, there were no statistically significant differences in serum LA, PCT, and CRP levels between the two groups (P＞0.05). After 1 week of treatment, serum LA, PCT, and CRP levels in the two groups decreased significantly, and the levels in the observation group were significantly lower than those in the control group, with statistically significant differences (P＜0.05). The ICU stays and twenty-eight-day mortality after therapy in the observation group were lower than those in the control group, with statistically significant differences (P＜0.05). ConclusionContinuous blood purification treatment can significantly decrease serum LA, PCT, and CRP levels in ICU patients with sepsis, which can effectively inhibit the inflammatory response, which plays an important role in promoting the recovery of patients and improving prognosis.

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