ObjectiveTo explore the risk factors for renal damage in patients with H-type hypertension, so as to provide a reference of effective prevention for patients occurring renal damage. MethodsThe clinical data of 186 patients with H-type hypertension diagnosed and treated in our hospital from January 2016 to January 2017 were retrospectively analyzed and divided into normal group (GFR≥90mL/L, 148 patients in total) and injury group (GFR＜90 mL/L, 38 patients in total) according to the glomerular filtration rate (GFR). Gender, age, course of disease, systolic blood pressure, retinol binding protein, homocysteine (Hcy), Cystatin C (Cys-C), β2 microglobulin (β2-MG), serum creatinine, and uric acid etc. were compared and analyzed between the two groups. Multivariate logistic regression analysis was performed to analysed the factors for renal damage in patients with H-type hypertension. ResultsUnivariate analysis results showed that Patients with H-type hypertension in the injury group obtained significantly higher expression levels of Hcy, Cys-C, β2-MG compared to the normal group, with statistically significant differences (P＜0.05). Multivariate logistic regression analysis results showed that Hcy＞20.13 μmol/L, Cys-C＞1.83 mg/L, β2-MG＞3.12 mg/L were independent risk factors for renal damage in patients with H-type hypertension (P＜0.05) . ConclusionElevated levels of Hcy, Cys-C, and β2-MG are closely related to renal damage in patients with H-type hypertension. Early detection and targeted intervention may be conducive to preventing renal damage, and improving prognosis.

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