ObjectiveTo explore the relationship between expressions of serum homocysteine, plasma C-reactive protein and D-dimer and affective disorder in patients with intractable epilepsy. MethodsA total of 80 patients confirmed as intractable epilepsy in the Department of Neurology of our hospital from 1st December, 2018 to 15th October, 2019 were selected. Hamilton anxiety and depression scales (HAMA, HAMD) were used to evaluate the condition of anxiety and depression in patients. According to the evaluation results, patients were divided into non-affective disorder group (13 cases), mild affective disorder group (47 cases) and moderate to severe affective disorder group (20 cases). The levels of serum Hcy, plasma CRP and D-D between the three groups were detected and compared. Pearson correlation analysis was used to analyze the relationship between affective disorder and serum Hcy, plasma CRP and D-D levels in patients with intractable epilepsy. ResultsThere were significant differences in serum Hcy and plasma CRP levels between the three groups (P＜0.05), which presented in a descending order with moderate to severe affective disorder group, mild affective disorder group, and non-affective disorder group. There was no significant difference in plasma D-D level between the three groups (P＞0.05). Pearson correlation analysis results showed that affective disorders in patients with intractable epilepsy were positively correlated with their serum Hcy levels (r=0.674), and were not related to their plasma CRP and D-D levels. ConclusionSerum Hcy and plasma CRP levels in patients with intractable epilepsy complicated with affective disorders significantly increase. Serum Hcy levels are closely related to the occurrence of affective disorders in patients with intractable epilepsy.

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