ObjectiveTo explore the relationship between methylenetetrahydrofolate reductase (MTHFR) of gene polymorphism and adverse pregnancy outcomes. MethodsA total of 130 child-bearing women with adverse pregnancy outcomes admitted to our hospital from August 2017 to August 2019 were selected as observation group, whereas 110 fertile women without adverse pregnancy history visited to our hospital during the same period were selected as control group. The genotype and allele frequency distribution of MTHFR at locus A1298C and C677T were detected and compared between the two groups. ResultsThere were statistically significant differences of AA, AC, CC genotypes at locus A1298C and CC, CT, TT genotypes at C677T locus of MTHFR, and of A,C allele frequency distribution at locus A1298C and C,T at locus C677T of MTHFR between the two groups (P＜0.05). ConclusionPolymorphism of MTHFR may be related to the occurrence of adverse pregnancy outcomes.

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