ObjectiveTo explore the expressions and clinical significance of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) in papillary thyroid carcinoma. MethodsA total of 30 patients firstly diagnosed as papillary thyroid carcinoma and 30 patients with benign thyroid lesions who were treated in our hospital from June 2017 to June 2018 were selected as the research subjects. Patients in both groups were given surgical treatment. The expressions of CA125 and CA19-9 in the lesion tissues were detected in both groups by immunohistochemical Max Vision two-step method. ResultsThe positive expression rates of CA125 and CA19-9 in the lesion tissues of patients in the papillary thyroid carcinoma group were 66.7% and 80.0%, respectively, whereas the positive expression rates mentioned above in the benign thyroid lesions group were 20.0% and 26.7%, respectively, with statistically significant differences (P＜0.05). CA19-9 positive lesion tissues showed linear coloring of the cell lumen edge or cell membrane, and mainly presented as platy, whereas CA125 positive lesion tissues showed the linear shape of the cell lumen edge or the top of the cell membrane, and most periplasm interpreted weak coloring. There were no statistically significant differences in the positive expression rates of CA125 and CA19-9 among patients with papillary thyroid carcinoma in different genders, age, tumor diameter, lymph node metastasis, clinical TNM stages, and the number of tumor nodules (P＞0.05). ConclusionCA125 and CA19-9 interpret high expressions in papillary thyroid carcinoma, which has an important reference value for the differential diagnosis of papillary thyroid carcinoma or benign thyroid lesions.

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