内科

目的探讨亚甲基四氢叶酸还原酶（MTHFR）基因多态性与不良妊娠结局的关系。方法选取2018年6月至2019年6月我院收治的既往存在不良妊娠结局的育龄期女性120例为观察组，选择同期在我院就诊的无不良妊娠病史的育龄期妇女120例为对照组，检测比较两组妇女的MTHFR C677T、A1298C位点基因型、等位基因频率分布情况。结果两组妇女C677T位点的基因型（CC、CT、TT）、A1298C位点的基因型（AA、AC、CC）频率分布比较差异均有统计学意义（P＜0.05）。两组妇女C677T位点的等位基因（C、T）、A1298C位点的等位基因（A、C）频率分布比较差异均有统计学意义（P＜0.05）。结论MTHFR基因多态性可能与育龄期女性不良妊娠结局的发生有关。

ObjectiveTo explore the relationship between polymorphism of methylenetetrahydrofolate reductase (MTHFR) and adverse pregnancy outcomes. MethodsA total of 120 women in childbearing age who previously had adverse pregnancy history admitted to our hospital from June 2018 to June 2019 were selected as observation group, and 120 women of childbearing age without adverse pregnancy history in our hospital during the same period were selected as control group. The genotypes and allele frequency distribution of MTHFR at C677T and A1298C locus were compared between the two groups. ResultsThere were statistically significant differences in the frequency distribution of genotypes (CC, CT, TT) at C677T locus and genotypes (AA, AC, CC) at locus A1298C between the two groups (P＜0.05). The frequency distribution of allele (C and T) at locus C677T and allele (A and C) at A1298C locus had statistically significant differences (P＜0.05). ConclusionMTHFR polymorphism may be related to the adverse pregnancy outcomes occurrence in childbearing age women.

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