ObjectiveTo investigate the correlation between carotid atherosclerosis and bone metabolism level in perimenopausal women. MethodsA total of 89 perimenopausal women who underwent a physical examination at the Health Management Center of Shenzhen Hospital of Southern Medical University from March 2017 to July 2019 were selected as the research objects, in order to calculate the incidence of carotid atherosclerosis in perimenopausal women. Univariate analysis and Pearson correlation analysis were performed on the relationship between age and other factors and carotid artery intima-media thickness (IMT) for perimenopausal women. Multivariate logistic regression analysis was performed on the risk factors for carotid atherosclerosis in perimenopausal women. ResultsThe incidence of carotid atherosclerosis in perimenopausal women was 28.09%. The results of univariate analysis showed that the BMI, IMT, the prevalence of hypertension and diabetes mellitus, TG level, and PTH content of perimenopausal women in the carotid atherosclerosis group were significantly higher than those in the normal group, whereas HDL-C, 25(OH)D3, CTX and osteocalcin contents were significantly lower than those in the normal group, with statistically significant differences (P＜0.05). The results of Pearson correlation analysis showed that BMI, TC, LDL-C, and PTH were positively correlated with IMT, while HDL-C, 25(OH)D3, CTX and osteocalcin levels were negatively correlated with IMT in perimenopausal women. The results of multivariate logistic regression analysis showed that BMI (≥25 kg/m2), hypertension, diabetes mellitus, TG (≥1.7 mmol/L), osteocalcin (≤16.0 ng/mL) were risk factors for carotid atherosclerosis in perimenopausal women. ConclusionThe occurrence of carotid atherosclerosis in perimenopausal women is closely related to abnormal bone metabolism. Hypertension, diabetes mellitus, abnormal lipid metabolism, obesity and decreased osteocalcin content are important risk factors for carotid atherosclerosis in perimenopausal women.

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