ObjectiveTo analyze the effect of hemodialysis combined with hemodiafiltration on nutritional status and microinflammatory factors and cardiac function in patients with diabetic nephropathy. MethodsA total of 150 patients with diabetic nephropathy admitted to our hospital from January 2018 to October 2019 were selected, and they were divided into control group (76 cases) and observation group (74 cases) by the random number method. The control group was treated with hemodialysis, whereas the observation group was treated with hemodialysis combined with hemodiafiltration, for a four-month treatment course. The nutritional status, microinflammatory indicators and changes in the cardiac structure before and after treatment were compared between the two groups. ResultsBefore treatment, there were no statistically significant differences in the levels of hemoglobin (Hb), serum albumin (Alb), ferritin (SF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reaction protein (CRP), and left ventricular end-systolic diameter (LVEDs), left ventricular end-diastolic diameter (LVEDd), left ventricular posterior wall thickness (LVPWT), as well as left ventricular diameter (LVD) between the two groups (P＞0.05). After 4 months of treatment, the observation group yielded higher levels of Hb, Alb, and SF, whereas lower levels of IL-6, TNF-α, and CRP, and smaller LVEDs, LVEDd, LVPWT, and LVD as compared with the control group, with statistically significant differences (P＜0.05). ConclusionHemodialysis combined with hemodiafiltration can effectively improve the nutritional status of patients with diabetic nephropathy, decrease the levels of microinflammatory factors, and improve the cardiac structure in patients.

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