ObjectiveTo investigate the effect of continuous blood purification on inflammatory factors and renal function in patients with severe acute pancreatitis (SAP) complicated with acute kidney injury (AKI). MethodsA total of 90 patients with SAP complicated with AKI who were treated in our hospital from April 2016 to June 2019 were selected, and they were divided into two groups according to the random number method, with 45 cases in each group. The control group was given comprehensive treatments including routine pain relief, abrosia, nutritional support, inhibition of pancreatic enzyme secretion, spasmolysis, gastrointestinal decompression, improvement of microcirculation, early fluid resuscitation, anti-infection, and maintenance of electrolyte balance, based on which the observation group was treated with continuous blood purification. The tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), interleukin-6 (IL-6) and serum creatinine (SCr), blood urea nitrogen (BUN) levels, and APACHEⅡ scores of the two groups before treatment and 72 hours after treatment were detected and compared. ResultsBefore treatment, there were no statistically significant differences in the levels of TNF-α, IL-10, IL-6, SCr, BUN, and APACHEⅡ scores between the two groups (P＞0.05). After 72 hours of treatment, the levels of TNF-α, IL-10, IL-6, SCr, BUN and APACHEⅡ scores of the observation group were significantly lower than those of the control group, with statistically significant differences (P＜0.05). ConclusionOn the basis of conventional treatment, continuous blood purification treatment for patients with SAP complicated with AKI can significantly decrease the levels of inflammatory factors, effectively improve renal function, which is beneficial to improve the prognosis of patients, and is worthy of promotion and application.

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