ObjectiveTo explore the expression levels of IL-6, sIL-6R and sgp130 in patients with paraquat poisoning and their relationship with the prognosis of patients. MethodsA total of 60 patients with paraquat poisoning admitted to our hospital from January 2017 to July 2019 were selected as the poisoning group, and 60 volunteers who came to our hospital for physical examination during the same period were selected as the control group. The patients in the poisoning group were divided into favorable prognosis group (38 cases) and poor prognosis group (22 cases) according to the prognosis of the patients. The serum IL-6, sIL-6R, and sgp130 levels were compared between patients in the poisoning group and healthy volunteers in the control group, the favorable prognosis group and the poor prognosis group. The Spearman correlation analysis was performed on the relationship between serum IL-6, sIL-6R, sgp130 levels and prognosis of poisoning patients. ResultsAs compared with the healthy volunteers in the control group and the patients in the poor prognosis group, the poisoning group yielded higher levels of serum IL-6, sIL-6R and sgp130, whereas the favorable prognosis group yielded lower levels mentioned above, with statistically significant differences (P＜0.05). The levels of serum IL-6, sIL-6R, and sgp130 in poisoned patients admitted to the hospital were negatively correlated with the prognosis of the patients (r=-0.857, r=-0.720, r=-0.688, all P＜0.05). ConclusionThe serum IL-6, sIL-6R, and sgp130 levels of patients with paraquat poisoning significantly increase, and they are closely related to the prognosis of the patients. Effectively decreasing the levels of serum IL-6, sIL-6R, and sgp130 in patients may prevent further lung injury in patients and improve their prognosis.

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