ObjectiveTo compare the clinical effects between azithromycin combined with N-acetylcysteine (NAC) and azithromycin combined with ambroxol hydrochloride (AH) in the treatment of children bronchopneumonia (CBP). MethodA total of 110 CBP children admitted to our hospital from November 2019 to October 2020 were selected and divided into control group and observation group by the random number method, with 55 cases in each group. The control group was treated with azithromycin + AH, whereas the observation group was treated with azithromycin + NAC. After 5 days of continuous treatment, the clinical symptoms improvement time, the pre- and post-treatment inflammatory indexes and lung function levels were compared between the two groups. ResultsCompared with the control group, the observation group yielded shorter disappeared time of expectoration, fever and lung rale, with statistically significant differences (P＜0.05). Before treatment, there were no statistically significant differences in the levels of serum interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α), forced expiratory volume in the first second (FEV1), and forced vital capacity (FVC) (P＞0.05). After 5 days of treatment, the levels of serum IL-6, CRP, and TNF-α significantly decreased, whereas the levels of FEV1 and FVC significantly increased in both groups, and the observation group yielded lower levels of serum IL-6, CRP and TNF-α, while higher levels of FEV1 and FVC as compared with the control group, with statistically significant differences (P＜0.05). ConclusionThe efficacy of azithromycin combined with NAC is superior to azithromycin combined with AH in the treatment of CBP, which can more quickly improve the clinical symptoms, decrease the levels of inflammatory factors, and improve lung functions in children.

无