内科

目的探讨参术地黄汤治疗肾精亏虚型脑梗死患者的临床效果及对患者炎症因子、神经功能的影响。方法选取2018年1月至2020年1月我院收治的脑梗死患者60例，根据入院时间分为对照组及观察组，每组30例。对照组患者给予常规抗凝、降压、调脂、纠正酸碱平衡紊乱、营养神经等治疗；观察组患者在对照组患者治疗的基础上给予参术地黄汤治疗，疗程1个月。比较两组患者的临床治疗效果；比较两组患者治疗前后的血清C反应蛋白（CRP）、白细胞介素-6（IL-6）、N端脑钠肽前体（NT-proBNP）、血肌酐、24 h尿蛋白水平及肌酐清除率。结果治疗1个月，观察组患者的治疗总有效率（93.3%）显著高于对照组（73.3%），差异有统计学意义（P＜0.05）。治疗1个月后，两组患者的血清CRP、IL-6、NT-proBNP水平及NIHSS评分均显著降低，观察组患者的炎症因子水平及NIHSS评分均显著低于对照组，差异有统计学意义（P＜0.05）；两组患者的血肌酐、24 h尿蛋白水平均显著降低，肌酐清除率显著增高；观察组的血肌酐、24 h尿蛋白水平显著低于对照组，肌酐清除率显著高于对照组，差异有统计学意义（P＜0.05）。结论在常规治疗的基础上结合参术地黄汤治疗，可有效提高肾精亏虚型脑梗死患者的临床治疗效果，缓解患者的炎症反应，减轻患者的神经功能损伤，改善患者的肾功能。

ObjectiveTo investigate the clinical effect of Shenshu Dihuang decoction in the treatment of patients with cerebral infarction in kidney essence deficiency type and its influence on inflammatory factors and nerve function. MethodsA total of 60 patients with cerebral infarction admitted to our hospital from January 2018 to January 2020 were selected, and they were divided into control group and observation group according to the time of admission, with 30 cases in each group. The control group was given treatment including conventional anticoagulation, blood pressure reduction, lipid regulation, acid-base balance disturbance correction, and neuro-nutrition, etc. based on which the observation group was given Shenshu Dihuang decoction, for a one-month treatment course. The clinical efficacy, pre- and post-treatment serum C-reactive protein (CRP), interleukin-6 (IL-6), N-terminal pro-B-type natriuretic peptide (NT-proBNP), serum creatinine, 24h urine protein levels and creatinine clearance rate were compared between the two groups. ResultsThe total effective rate of the observation group was (93.3%) significantly higher than that of the control group (73.3%) in a month of treatment, with a statistically significant difference (P＜0.05). After 1 month of treatment, the serum CRP, IL-6, NT-proBNP levels and NIHSS scores decreased significantly in both groups, and the observation group yielded lower levels of inflammatory factors and NIHSS score as compared with the control group, with statistically significant differences (P＜0.05). The serum creatinine and 24h urine protein levels decreased significantly, and the creatinine clearance rate increased significantly in both groups; compared with the control group, the observation group yielded lower serum creatinine and 24h urine protein levels, whereas a higher creatinine clearance rate, with statistically significant differences (P＜0.05). ConclusionCombining the treatment with Shenshu Dihuang decoction on the basis of conventional treatment can effectively improve the clinical efficacy of patients with cerebral infarction in kidney essence deficiency type, alleviate inflammatory responses, relieve nerve damages, and improve renal functions in patients.