内科

目的探讨阿仑膦酸钠联合阿司匹林治疗老年骨质疏松症患者的临床效果。方法选取2018年 5月至2019年8月我院收治的老年骨质疏松症患者102例作为研究对象，采用随机数字法分为观察组和对照组，每组51例。对照组患者给予阿仑膦酸钠治疗，观察组患者给予阿仑膦酸钠联合阿司匹林治疗，疗程1年。比较两组患者治疗前后的腰椎L2-L4骨密度、股骨颈骨密度、全髋骨密度，血清骨特异性碱性磷酸酶（BALP）水平、I型胶原 C端肽（β-CTX）水平、骨保护蛋白（OPG）水平；比较两组患者的临床疗效。结果治疗前，两组患者的腰椎L2-L4、股骨颈、全髋骨密度比较差异无统计学意义（P＞0.05）；治疗1年后，两组患者的腰椎L2-L4、股骨颈、全髋骨密度均明显提高，观察组的骨密度显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者的BALP、β-CTX、OPG水平比较差异无统计学意义（P＞0.05）。治疗1年后，两组患者的BALP、OPG水平均显著提高，β-CTX水平均显著降低；观察组患者的BALP、OPG水平显著高于对照组，β-CTX水平显著低于对照组，差异有统计学意义（P＜0.05）。观察组患者的治疗总有效率（94.1%）显著高于对照组（80.34%），差异有统计学意义（P＜0.05）。结论阿仑膦酸钠联合阿司匹林治疗能提高老年骨质疏松症患者的骨密度，改善患者的骨代谢状况，提高临床治疗效果。

ObjectiveTo explore the clinical effect of alendronate sodium combined with aspirin in the treatment of elderly patients with osteoporosis. MethodA total of 102 elderly patients with osteoporosis admitted to our hospital from May 2018 to August 2019 were selected as the research objects, and they were divided into observation group and control group by the random number method, with 51 cases in each group. The control group was treated with alendronate sodium, and the observation group was treated with alendronate sodium combined with aspirin, for a 1-year treatment course. The lumbar vertebra L2-L4 bone mineral density, femoral neck bone mineral density, total hip bone mineral density, serum bone alkaline phosphatase (BALP) levels, type I collagen C-terminal peptide (β-CTX) level, osteoprotegerin (OPG) level before and after treatment were compared between the two groups; meanwhile, the clinical efficacy was also compared between the two groups. ResultsThere were no statistically significant differences in the bone mineral density of the lumbar vertebra L2-L4, femoral neck and total hip between the two groups before treatment (P＞0.05). After 1 year of treatment, the bone mineral density of the lumbar vertebra L2-L4, femoral neck, and total hip of the two groups significantly increased, and the indicators of the observation group were significantly higher than those of the control group, with statistically significant differences (P＜0.05). Before treatment, there were no statistically significant differences in the levels of BALP, β-CTX and OPG between the two groups (P＞0.05). After 1 year of treatment, the levels of BALP and OPG significantly increased, whereas β-CTX level significantly decreased in both groups, and the observation group yielded higher levels of BALP and OPG, whereas a lower level of β-CTX as compared with the control group, and the differences were statistically significant (P＜0.05). The total effective rate of treatment in the observation group (94.1%) was significantly higher than that in the control group (80.34%), and the difference was statistically significant (P＜0.05). ConclusionAlendronate sodium combined with aspirin for treatment can increase the bone mineral density of elderly patients with osteoporosis, improve the bone metabolism in patients, and improve the clinical therapeutic effect.