ObjectiveTo investigate the effect of high flux hemodialysis on renal function and immune function in uremic patients with chronic renal failure. MethodsA total of 122 uremic patients with chronic renal failure admitted to our hospital from June 2019 to June 2020 were selected, and they were divided into two groups by the random number method, with 61 cases in each group. The control group was treated with conventional hemodialysis, and the study group was treated with high flux hemodialysis, for a 28-day treatment course. The clinical efficacy was compared between the two groups. The renal function, immunoglobulin level and complications of the two groups were detected and compared. ResultsAfter a course of treatment, the total effective rate of treatment in the study group (96.72%) was significantly higher than that in the control group (85.25%), with a statistically significant difference (P＜0.05). The blood urea nitrogen (BUN), serum creatinine (SCr) and β2-microglobulin (β2-MG) levels of the study group were significantly lower than those of the control group, while the urea nitrogen clearance index (Kt/V) of the study group was significantly higher than that of the control group, with statistically significant differences (P＜0.05). The levels of immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) in the study group were significantly higher than those in the control group, with statistically significant differences (P＜0.05). During the treatment, the incidence of complications including skin itching and heart disease etc. in the study group (3.28%) was significantly lower than that in the control group (13.11%), with a statistically significant difference (P＜0.05). ConclusionHigh flux hemodialysis can improve the renal function of uremic patients with chronic renal failure, improve the immune system function and clinical efficacy, and reduce the occurrence of complications in patients.

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