ObjectiveTo compare the clinical effects of double filtration plasmapheresis (DFPP) and single plasmapheresis in the treatment of patients with lupus nephritis. MethodsA total of 34 patients with lupus nephritis admitted to our hospital from August 2017 to December 2019 were selected and divided into observation group and control group by the random number method, with 17 cases in each group. The observation group was treated with DFPP, whereas the control group was treated with single plasmapheresis. The scores of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), serum complement C3, 24-hour proteinuria (24hUP), serum immunoglobulin G (IgG), anti ds-DNA antibody, serum albumin (ALB) and fibrinogen (FIB) were compared between the two groups before and 2 weeks after treatment. The adverse reactions of the two groups were compared during the treatment. ResultsAfter 2 weeks of treatment, SLEDAI scores, 24hUP, IgG, anti ds-DNA antibody and FIB levels of the two groups significantly decreased, and the levels mentioned above in the observation group were significantly lower than those in the control group (P＜0.05). The levels of C3 and ALB significantly increased, and compared to the control group, the observation group yielded a higher level of C3 (P＜0.05), but there was no statistically significant difference in ALB level between the two groups (P＞0.05). During the treatment, there was no statistically significant difference in the incidence of catheter infection and hypotension between the two groups (P＞0.05). The incidence of allergic reaction and citric acid reaction in the control group was significantly higher than that in the observation group, with a statistically significant difference (P＜0.05). ConclusionsDouble plasmapheresis in the treatment of lupus nephritis is superior to single plasmapheresis; however, it will cause fibrinogen reduction in the body, which should be paid attention to in clinical application.

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