ObjectiveTo explore the clinical effect of heterozygous blood purification on chronic renal failure and its influence on micro inflammatory response and life quality. MethodsA total of 78 patients with chronic renal failure admitted to our hospital from January 2017 to May 2019 were selected as the research objects, and they were divided into control group and observation group by the random number method, with 39 cases in each group. The control group was treated with simple hemodialysis, whereas the observation group was treated with heterozygous blood purification (hemoperfusion combined with hemodialysis), for a three-month treatment course. The renal function, micro inflammatory indexes levels and life quality were compared between the two groups before and after treatment. ResultsBefore treatment, there were no statistically significant differences in the levels of serum creatinine (Scr), urea nitrogen (BUN), and serum creatinine clearance (Ccr) between the two groups (P＞0.05). After 3 months of treatment, compared with the control group, the observation group yielded lower levels of Scr and BUN, while a higher level of Ccr, with statistically significant differences (P＜0.05). Before treatment, there were no statistically significant differences in high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels between the two groups (P＞0.05). After 3 months of treatment, the observation group yielded lower levels of hs-CRP, TNF-α, and IL-6, whereas higher scores of mental state, physical function and social function as compared with the control group, with statistically significant differences (P＜0.05). ConclusionThe clinical effect of heterozygous blood purification in the treatment of patients with chronic renal failure is significantly superior to that of simple hemodialysis, which can more effectively improve renal function, reduce micro inflammatory response, and improve life quality.

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