ObjectiveTo explore the effects of candesartan cilexetil combined with Shenyankangfu tablets on inflammatory response and renal function in patients with diabetic nephropathy. MethodsA total of 82 patients with diabetic nephropathy admitted to our hospital from May 2018 to May 2019 were selected and divided into control group and observation group by the random number method, with 41 cases in each group. The patients in the control group were treated with candesartan cilexetil, whereas the patients in the observation group were treated with candesartan cilexetil combined with Shenyankangfu tablets, for a 3-month treatment course. The renal function, 24-hour urinary protein quantity and micro-inflammatory index levels were compared between the two groups. ResultsBefore treatment, there were no statistically significant differences in the levels of urea nitrogen (BUN), serum creatinine (Scr), visfatin, 24-hour urinary protein quantity, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) between the two groups (P＞0.05). After 3 months of treatment, the observation group yielded lower levels of BUN, Scr, visfatin, 24-hour urinary protein quantity, CRP, TNF-α and IL-6 in the comparison of the control group, with statistically significant differences (P＜0.05). ConclusionCandesartan cilexetil combined with Shenyankangfu tablets in the treatment of patients with diabetic nephropathy can significantly relieve the inflammatory response and prominently improve renal function in patients.

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