ObjectiveTo explore the clinical effects of self-expanded metal stent implantation combined with radiofrequency ablation (RFA) via endoscopic retrograde cholangiopancreatography (ERCP) in the palliative treatment of patients with malignant obstructive jaundice. MethodsA total of 78 patients with malignant obstructive jaundice admitted to our hospital from August 2018 to November 2019 were selected, and they were divided into combination group and routine group by the random number method, with 39 cases in each group. Self-expanded metal stents were implanted into the patients in the routine group, based on which the patients in the combination group were treated with RFA via ERCP. The postoperative liver function, jaundice relief, complications, biliary patency time and 1-year survival rate were compared between the two groups. ResultsAfter 7 days of surgery, the levels of total bilirubin (TBIL), gamma-glutamyltransferase (γ-GT) and alkaline phosphatase (ALP) significantly decreased in both groups, and the combination group yielded lower levels as compared with the routine group, with statistically significant differences (P＜0.05). There was no statistically significant difference in the jaundice remission rate between the two groups (97.44% vs. 84.62%, P＞0.05). There was no statistically significant difference in the complication rate between the two groups (P＞0.05). The postoperative biliary patency time in the combination group was significantly longer than that in the routine group, and the 1-year survival rate was significantly higher than that in the routine group, with statistically significant differences (P＜0.05). ConclusionSelf-expanded metal stent implantation combined with RFA via ERCP for the treatment of patients with malignant obstructive jaundice can effectively improve liver function, significantly prolong biliary patency time, and prominently increase 1-year survival rate in patients.

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