内科

目的探讨宫颈上皮内瘤变（CIN）患者宫颈锥切术后发生高危型人乳头状瘤病毒（HPV）持续感染的影响因素，为有效预防提供参考。方法选择2019年6月至2020年6月在我院收治的60例 CIN患者作为研究对象，对患者进行宫颈锥切术治疗。术后随访6个月，对患者进行2次HPV DNA检测，根据检测结果将患者分为感染组（发生高危型HPV持续感染）和非感染组（未发生高危型HPV持续感染），比较两组患者的年龄、婚姻状况、不良嗜好、不良性行为、妊娠次数、术后用药情况、术后切缘碘试验或醋酸白试验结果；对CIN患者宫颈锥切术后发生高危型HPV持续感染的影响因素进行多因素Logistic回归分析。结果60例CIN患者宫颈锥切术后发生高危型HPV持续感染11例，感染发生率为18.33%。感染组和非感染组患者的年龄、婚姻状况、不良嗜好、术后用药情况比较，差异无统计学意义（P＞0.05）；感染组患者的不良性行为发生率、术后切缘碘试验或醋酸白试验结果阳性率以及妊娠次数显著高（多）于非感染组患者，差异有统计学意义（P＜0.05）。多因素Logistic回归分析结果显示，不良性行为、妊娠次数、术后切缘碘试验或醋酸白试验阳性是CIN患者宫颈锥切术后发生高危型HPV持续感染的独立危险因素。结论不良性生活、妊娠次数、术后切缘碘试验或醋酸白试验阳性是CIN患者宫颈锥切术后发生高危型HPV持续感染的独立危险因素，采取针对性措施加以预防，可望降低感染的风险。

ObjectiveTo investigate the influencing factors for high- risk human papillomavirus (HPV) persistent infection after cervical conization in patients with cervical intraepithelial neoplasia (CIN), to provide a reference for effective prevention. MethodsA total of 60 CIN patients admitted to our hospital from June 2019 to June 2020 were selected as the research objects, and cervical conization was conducted to the patients. All patients were followed up for 6 months, and two times of the HPV DNA tests were conducted in patients. According to the test results, the patients were divided into infection group (persistent infection of high-risk HPV occurred) and non infection group(No persistent infection of high-risk HPV occurred). The age, marital status, bad habits, bad sexual behavior, number of pregnancies, postoperative medication, postoperative incisal edge iodine test or acetic acid white test were compared between the two groups. Logistic regression analysis was performed on the influencing factors for high-risk HPV persistent infection after cervical conization in patients with CIN. ResultsHigh-risk HPV persistent infection occurred in 11 cases (18.33%) of 60 CIN patients after undergoing cervical conization. There were no statistically significant differences in age, marital status, bad habits and postoperative medication between the infection group and the non infection group (P＞0.05). The infection group yielded higher incidence of bad sexual behavior, positive rates of postoperative incisal edge iodine test or acetic acid white test, and more number of pregnancies as compared with the non infection group, with statistically significant differences (P＜0.05). Multivariate logistic regression analysis results revealed that bad sexual behavior, number of pregnancies, positive results of postoperative incisal edge iodine test or acetic acid white test were independent risk factors for high-risk HPV persistent infection after cervical conization in CIN patients. ConclusionBad sexual behavior, number of pregnancies, positive results of postoperative incisal edge iodine test or acetic acid white test are independent risk factors for high-risk HPV persistent infection after cervical conization in CIN patients. Pertinent strategies should be taken to prevent, which may reduce the infection risk for high-risk HPV persistent infection.