ObjectiveTo explore the clinical effect and safety of modified electroconvulsive therapy in the treatment of patients with major depressive disorder. MethodsA total of 86 patients with major depressive disorder who were treated in our hospital from September 2018 to September 2019 were selected as the research objects, and they were divided into control group and observation group according to the random number method, with 43 cases in each group. The control group was given traditional electroconvulsive therapy, whereas the observation group was given modified electroconvulsive therapy. Each patient was treated 6 to 12 times. The Clinical Global Impression Severity Scale (CGI-S) scores and plasma kynurenine levels of the two groups before and after treatment were compared. The clinical efficacy and adverse reactions of the two groups were compared. ResultsBefore treatment, there were no statistically significant differences in CGI-S scores and kynurenine levels between the two groups (P＞0.05). After the treatment course, the observation group yielded lower CGI-S score and kynurenine level in comparison with the control group, with statistically significant differences (P＜0.05). The total effective rate in the observation group (93.02%) was significantly higher than that in the control group (76.74%), with a statistically significant difference (P＜0.05). The incidence of adverse reactions in the observation group (27.91%) was significantly lower than that in the control group (48.84%) from the beginning to 2 months after the end of treatment, with a statistically significant difference (P＜0.05). ConclusionThe efficacy of modified electroconvulsive therapy is significantly superior to traditional electroconvulsive therapy in the treatment of patients with major depression disorder. It can significantly decrease the levels of kynurenine in patients, and reduce the occurrence of adverse reactions.

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