内科

目的观察中药外洗辅助治疗小儿手足口病（HFMD）的效果以及对患儿炎症因子、免疫球蛋白水平的影响。方法选取2018年2月至2020年12月我院收治的HFMD患儿105例为研究对象，采用随机数字法分为对照组（52例）和观察组（53例）。对照组患儿在常规治疗的基础上给予清水沐浴，观察组患儿在常规治疗的基础上给予中药甘露消毒丹外洗，疗程均为1周。比较两组患儿治疗前后的中医证候积分、血清炎症因子以及血清免疫球蛋白水平。结果干预前，两组患儿的发热、口腔溃疡、皮肤疱疹、恶心呕吐、腹泻评分比较，差异无统计学意义（P＞0.05）；干预1周末，两组患儿的发热、口腔溃疡、皮肤疱疹、恶心呕吐、腹泻评分均显著降低，观察组患儿的评分显著低于对照组，差异有统计学意义（P＜0.05）。干预前，两组患儿的白细胞（WBC）计数、超敏C-反应蛋白（hs-CRP）水平比较，差异无统计学意义（P＞0.05）；干预1周末，两组患儿的WBC计数、hs-CRP水平均显著降低，观察组患儿的水平显著低于对照组，差异有统计学意义（P＜0.05）。干预前，两组患儿的IgA、IgG、IgM水平比较，差异无统计学意义（P＞0.05）；干预1周末，两组患儿的IgA、IgG、IgM水平均显著增高，观察组患儿的水平显著高于对照组，差异有统计学意义（P＜0.05）。结论中药外洗辅助治疗小儿手足口病可明显改善临床症状，降低炎症因子水平，提高血清免疫球蛋白水平。

ObjectiveTo observe the effect of external washing of traditional Chinese medicine in the adjuvant treatment of children with hand-foot-mouth disease (HFMD) and its influence on the levels of serum inflammatory factors and immunoglobulin. MethodA total of 105 children with HFMD admitted to our hospital from February 2018 to December 2020 were selected as the research subjects, and they were divided into control group (52 cases) and observation group (53 cases) according to the random number method. The children in the control group had water bath based on the routine treatment, whereas the children in the observation group had external washing using traditional Chinese medicine Ganlu Xiaodu micropills based on the routine treatment, for one-week treatment course. The traditional Chinese medicine syndrome scores, the levels of inflammatory factors and serum immunoglobulin were compared between the two groups. ResultsBefore intervention, there were no statistically significant differences in the scores of fever, oral ulcer, cutaneous herpes, nausea and vomiting, and diarrhea between the two groups (P＞0.05). After one week of intervention, the scores mentioned above significantly decreased in both groups, and the observation group yielded lower scores as compared with the control group, with statistically significant differences (P＜0.05). Before intervention, there were no statistically significant differences in white blood cell (WBC) counts and high-sensitivity C-reactive protein (hs-CRP) levels between the two groups (P＞0.05). After one week of intervention, the abovementioned indicators significantly decreased in both groups, and the observation group yielded lower levels in comparison with the control group, with statistically significant differences (P＜0.05). Before intervention, there were no statistically significant differences in the levels of IgA, IgG and IgM between the two groups (P＞0.05). After one week of intervention, the levels as above significantly increased in both groups, and the levels in the observation group were significantly higher than those in the control group, with statistically significant differences (P＜0.05). ConclusionExternal washing of traditional Chinese medicine in the adjuvant treatment of HFMD children can significantly improve the clinical symptoms, decrease the levels of serum inflammatory factors and increase the levels of serum immunoglobulin.