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奥氮平联合鼓圈音乐治疗老年精神分裂症患者临床疗效观察▲
Observation of clinical efficacy on olanzapine combined with drum circle music on elderly schizophrenia

内科 202116卷05期 页码:612-615

作者机构:南宁市第五人民医院精神科,广西南宁市530001

基金信息:▲基金项目:广西壮族自治区卫生健康委员会自筹经费科研项目(Z20190778) *通信作者:覃电泽,广西南宁市第五人民医院精神科,电子邮箱 qindianze888@163.com

DOI:DOI:10.16121/j.cnki.cn45-1347/r.2021.05.13

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目的探讨奥氮平联合鼓圈音乐治疗老年精神分裂症患者的临床疗效。方法选取2019年9月至2020年12月在广西南宁市第五人民医院住院治疗的老年精神分裂症患者120例为研究对象,采用随机数字法分为研究组和对照组,每组60例。对照组患者给予奥氮平治疗,研究组患者给予奥氮平联合鼓圈音乐治疗,疗程12周。比较两组患者治疗前后的简明精神病量表(BPRS)评分;比较两组患者治疗期间的药物不良反应量表(TESS)评分以及不良反应发生情况。结果治疗前,两组患者的BPRS总分及各因子评分比较,差异均无统计学意义(P>0.05)。治疗12周末,研究组患者的BPRS总分、焦虑忧郁得分、缺乏活力得分、思维障碍得分、激活性得分、敌对猜疑得分均显著低于对照组,差异均有统计学意义(P<0.05);研究组患者的治疗总有效率(90.0%)高于对照组(74.6%),差异有统计学意义(P<0.05)。治疗过程中,研究组患者的TESS评分及不良反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论奥氮平联合鼓圈音乐治疗老年精神分裂症患者的临床疗效显著,药物不良反应轻微,值得推广应用。
ObjectiveTo explore the clinical efficacy of olanzapine combined with drum circle music in the treatment of elderly patients with schizophrenia. MethodsA total of 120 elderly patients with schizophrenia who were hospitalized in the Fifth People′s Hospital of Nanning from September 2019 to December 2020 were selected as the research objects. They were divided into study group and control group by the random number method, with 60 cases in each group. Patients in the control group were treated with olanzapine, while patients in the study group were treated with olanzapine combined with drum circle music, for a 12-week treatment course. The Brief Psychiatric Rating Scale (BPRS) scores of the two groups before and after treatment were compared. The Treatment Emergent Symptom Scale (TESS) scores and the occurrence of adverse reactions during the treatment were compared between the two groups. ResultsBefore treatment, there were no statistically significant differences between the total scores of BPRS and the scores of each factor between the two groups (P>0.05). At the end of the 12th week of treatment, the total scores of BPRS, the scores of each factor including anxiety and depression, lack of vitality, thought disturbance, excitement, and hostility and suspiciousness of the study group were significantly lower than those of the control group, with statistically significant differences (P<0.05). The study group yielded a higher total effective rate (90.0%) as compared with the control group (74.6%), with a statistically significant difference (P<0.05). During the course of treatment, the TESS scores and the incidence of adverse reactions in the study group were lower than those in the control group, with statistically significant differences (P<0.05). ConclusionOlanzapine combined with drum circle music has significantly clinical efficacy in the treatment of elderly patients with schizophrenia, and the adverse drug reactions are mild, thus it is worthy of promotion and application.

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