目的探讨中西医结合治疗对咳嗽变异型哮喘患者肺功能的影响。方法选择2011年1月至2013年1月入住我院治疗的咳嗽变异型哮喘患者76例,随机分为观察组和对照组各38例。对照组患者口服茶碱控释片0.1 g,2次/d;口服酮替芬1 mg,2次/d;雾化吸入舒利迭(沙美特罗替卡松粉吸入剂,50 μg ∶500 μg)治疗,2次/d。观察组在同对照组治疗的基础上加用中药治疗。比较两组患者的临床疗效及治疗前后肺功能(FEVl、FEVl%预计值、FEVl/FVC)的变化情况。结果观察组患者治疗总有效率为86.8%,对照组治疗总有效率为68.4%,观察组患者的临床疗效明显优于对照组(P=0.020)。两组患者治疗前FEVl、FEVl%预计值、FEVl/FVC比较,无统计学意义(P>0.05),治疗后两组患者上述指标明显高于治疗前(P<0.05),且观察组患者FEVl%预计值、FEVl/FVC高于对照组(P<0.05)。结论中西医结合治疗可以提高咳嗽变异型哮喘患者的疗效,改善肺功能,值得广泛推广和应用。
ObjectiveTo investigate the impact of integrated Chinese and western medicine on lung function in patients with cough variant asthma. Methods76 patients with cough variant asthma between January 2010 and January 2013 in our hospital were randomly divided into observation group and control group, with 38 cases in each. The control group were treated with theophylline release tablets (0.1g, 2 times a day, p.o), ketotifen(1 mg, 2 times a day, p.o), and seretide [(salmeterol xinafoate and fluticasone propionate inhalation powder, 50μg: 500μg), 2 times a day, inhalation]. The observation group were treated with Chinese medicine based on western medicine. Curative effects were compared between the two groups, while lung function(indicators FEVl, FEVl% predicted value, FEVl/FVC) in two groups were compared before and after treatment. ResultsTotal effective rate of observation group and control group was 86.8% and 68.4%, respectively. The clinical curative effect in the observation group was significantly better than that in the control group (P=0.020). There were no significant difference in FEVl, FEVl% predicted value, and FEVl/FVC between the two groups before treatment(P>0.05).After treatment, all indexes in the two groups were higher than those before treatment, and FEVl% predicted value and FEVl/FVC in the observation group were higher than that in the control group(P<0.05). ConclusionIntegrated Chinese medicine and western medicine can increase therapeutic effect and improve lung function in patients cough variant asthma, which is worthy to be widely employed.