ObjectiveTo investigate the clinical effect of albumin combined with continuous renal replacement therapy (CRRT) in patients with capillary leak syndrome. MethodsA total of 64 patients with capillary leak syndrome admitted to our hospital from February 2018 to February 2021 were divided into observation group and control group according to the random number method, with 32 cases in each group. Based on the treatment of sepsis, burns and other primary diseases therapy and basic treatment, patients in the control group were treated with hydroxyethyl starch sodium chloride, while patients in the observation group were treated with albumin combined with CRRT, with 2-week continuous treatment. The survival rate of 1 month after treatment was compared between the two groups. The liver and kidney function of the two groups were detected and compared before and after treatment for 2 weeks. After 2 weeks of treatment, the scores of acute physiology and chronic health evaluation Ⅱ (APACHE-Ⅱ) and multiple organ dysfunction syndrome (MODS) were compared between the two groups. The improvement time of anasarca was compared between the two groups. The mean arterial pressure (MAP) and arterial oxygen partial pressure (PaO2) were detected and compared between the two groups after 2 weeks of treatment. ResultsAfter one month of treatment, the survival rate of the observation group (78.12%) was significantly higher than that of the control group (53.13%), with a statistically significant difference (P＜0.05). Before treatment, there were no statistically significant differences in the levels of alanine aminotransferase (ALT), albumin (Alb), urea nitrogen (BUN) and serum creatinine (SCr) between the two groups (P＞0.05). After 2 weeks of treatment, Alb levels increased significantly in both groups and the Alb level in the observation group was higher than that in the control group. The levels of ALT, BUN and SCr in the two groups decreased significantly, and the levels of BUN and SCr in the observation group were significantly lower than those in the control group, with statistically significant differences (P＜0.05). After 2 weeks of treatment, the 24 hours urine volume of the observation group was significantly greater than that of the control group, while the APACHE-Ⅱ score and MODS score were significantly lower than those of the control group, the levels of MAP and PaO2 were significantly higher than those in the control group, with statistically significant differences (P＜0.05). The improvement time of anasarca in the observation group was significantly shorter than that in the control group, with a statistically significant difference (P＜0.05). ConclusionAlbumin combined with CRRT can significantly improve the liver and kidney function and hemodynamic status of patients with capillary leakage syndrome, improve the condition and reduce the mortality of patients.

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