ObjectiveTo observe the clinical efficacy of donepezil tablets combined with auricular point pressing bean in the treatment of mild-to-moderate vascular dementia. Methods110 patients with mid-to-moderate vascular dementia treated in our hospital from February 2020 to April 2021 were enrolled as the research objects, and they were randomly divided into control group and observation group, with 55 cases in each group. The patients in the control group were given donepezil tablets treatment, while patients in the observation group received donepezil tablets combined with auricular point pressing bean, for a 30-day treatment course. The scores of activity of daily living scale (ADL), mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) were detected and compared between the two groups before and after treatment. The blood flow velocity of the anterior cerebral artery, middle cerebral artery and posterior cerebral artery were detected and compared by color doppler. And the levels of superoxide dismutase (SOD), homocysteine (Hcy) and lipid peroxide (LPO) were detected and compared between the two groups. The clinical efficacy and the occurrence of adverse reactions of the two groups were compared. ResultsDuring treatment, the control group dropped 3 cases and the observation group dropped 1 case. After 30 days of treatment, the scores of ADL, MMSE and MoCA in the two groups increased significantly, and the scores in the observation group were significantly higher than those in the control group, with statistically significant differences (P＜0.05). The blood flow velocity of anterior cerebral artery, middle cerebral artery and posterior cerebral artery significantly faster in both groups and were significantly greater in the observation group than those in the control group, with statistically significant differences (P＜0.05). After 30 days of treatment, SOD levels in both groups increased significantly, while the Hcy and LPO levels significantly decreased; the observation group reached higher level of SOD and lower levels of Hcy and LPO as compared with the control group, with statistically significant differences (P＜0.05). The total effective rate of treatment of the observation group (96.3%) was significantly higher than that of the control group (80.8%), with a statistically significant difference (P＜0.05). During the treatment, there was no statistically significant difference in the occurrence of adverse reactions between the two groups (P＞0.05). ConclusionDonepezil tablets combined with auricular point pressing bean can significantly improve the cognitive function, cerebral blood flow velocity and oxidative stress in patients with mild-to-moderate vascular dementia.

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